Making Oligonucleotides Better Biopharmaceuticals with Brush Polymers


主题:   Making Oligonucleotides Better Biopharmaceuticals with Brush Polymers主讲人:   Dr. Ke Zhang地点:   4 号学院楼生物研究所3083时间:   2018-10-15 15:00:00组织单位:   化学化工与生物工程学院


Dr. Ke Zhang obtained his BS degree in 2005 in Applied Chemistry fromNanjing University of Technology, China. He then studied polymer chemistry withProf. Karen Wooley at Washington University in St. Louis focusing onshell-crosslinked knedel-like nanoparticles and gene delivery, and obtained aPhD in Chemistry in 2009. Thereafter, Dr. Zhang was a postdoctoral fellow inthe laboratory of Prof. Chad Mirkin at Northwestern University to develophollow spherical nucleic acids, a carrier-free platform for gene regulation. In2012, Dr. Zhang joined Northeastern University as an assistant professor. Hiscurrent research includes the design and synthesis of unique polymersuperstructures, nucleic acid-polymer conjugates, and drug delivery.


This presentation focuses on the development of two new strategies fortransferring genetic materials to cells, which are mechanistically distinctfrom existing methods. The new systems rely upon the three-dimensionalarrangement of oligonucleotides or the use of biologically benign brushpolymers to enhance the properties of the nucleic acids. For instance, theoligonucleotide can acquire steric selectivity towards complementary strandsvs. proteins, which allows it to bypass many of the side effects associatedwith protein-DNA interactions.

视频:   摄影: 撰写:史向阳  信息员:陈娜  编辑:段然



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