Over expression and functional analyses of a protein nanocapsule, Encapsulin


主题:   Over expression and functional analyses of a protein nanocapsule, Encapsulin主讲人:   Masafumi Odaka地点:   材料学院楼A405时间:   2018-10-31 15:00:00组织单位:   


MasafumiOdaka教授1994年在东京工业大学生命科学与化学系获得博士学位,1994-2003年担任理研企业(RIKEN)生化系统实验室研究员,2004年至2014年担任东京农工大学生命科学技术系副教授,2014年至今担任秋田大学生命化学系教授,现任秋田大学工程科学研究院副院长。主要研究领域为蛋白质生物材料,已在Angew. Chem. Int. Ed.,J. Am. Chem. Soc.,Nat. Struct. Biol.等国际期刊发表一系列论文。


Nanoparticleshave been one of the most important key technologies among various scientificfields such as Biotechnology, Chemical Engineering, and Analytical Chemistry.Especially, nanoparticles using gold, quantum dots, and amphiphilic polymershave been extensively studied. Proteins are the most abundant nanomaterials inliving organisms and have been considered to have potentially very excellentcharacteristics in self-organization, chemical activities and structuralhomogeneity. However, studies treating proteins as nanoparticles have been verylimited except for some pioneering researches on ferritin and peripheral virusparticles, because of their complex structures, difficulties inself-organization and/or assembly, and instability against temperature, pH andorganic solvents. We have been studied a nanoparticle-forming protein,Encapsulin. It has a molecular weight of about 30k, and 60 copies of theEncapsulin subunit form a spherical particle with a thin T=1 icosahedral shellwith a diameter of 24 nm. Here, we show two kinds of Encapsulins from amesophilic bacterium, Rhodococcuserythropolis N771 and a hyperthermophilic one, Thermotoga maritima.


视频:   摄影: 撰写:范苏娜  信息员:星禧  编辑:段然



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